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    2,026 research outputs found

    Leadership in Compassionate Care: Final Report 2012

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    NHS Lothian
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    This report reflects the initiation, planning, running and the important outcomes emerging from the Leadership in Compassionate Care Programme. The team worked in close partnership across the School of Nursing, Midwifery and Social Care, Edinburgh Napier University and NHS Lothian. This report also shares the highlights, challenges and solutions to embed compassionate care education and nursing practice.Additional co-authors: Fiona Smith, Stephen DM Smith, Ria Tocher, and Anne Waug
    Stirling Online Research Repository (RIOXX)
    Stirling Online Research Repository
    Repository@Napier

    Civil society leadership in the struggle for AIDS treatment in South Africa and Uganda

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    'Business Department, School of Economics, Business & Accounting USP'
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    Includes abstract.Includes bibliographical references.This thesis is an attempt to theorise and operationalise empirically the notion of ‘civil society leadership’ in Sub-Saharan Africa. ‘AIDS leadership,’ which is associated with the intergovernmental institutions charged with coordinating the global response to HIV/AIDS, is both under-theorised and highly context-specific. In this study I therefore opt for an inclusive framework that draws on a range of approaches, including the literature on ‘leadership’, institutions, social movements and the ‘network’ perspective on civil society mobilisation. This framework is employed in rich and detailed empirical descriptions (‘thick description’) of civil society mobilisation around AIDS, including contentious AIDS activism, in the key case studies of South Africa and Uganda. South Africa and Uganda are widely considered key examples of poor and good leadership (from national political leaders) respectively, while the Treatment Action Campaign (TAC) and The AIDS Support Organisation (TASO) are both seen as highly effective civil society movements. These descriptions emphasise ‘transnational networks of influence’ in which civil society leaders participated (and at times actively constructed) in order to mobilise both symbolic and material resources aimed at exerting influence at the transnational, national and local levels
    Cape Town University OpenUCT
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    Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

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    'Springer Science and Business Media LLC'
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    Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity is significantly decreased when the FER tyrosine kinase phosphorylates CRMP2 at Y479 and Y499. The crystal structures of wild-type CRMP2 and CRMP2-Y479E reveal how mimicking phosphorylation prevents tetramerization of CRMP2. Depletion of FER or reducing its catalytic activity using sub-therapeutic doses of inhibitors increases paclitaxel-induced microtubule stability and cytotoxicity in ovarian cancer cells and in vivo. This work provides a rationale for inhibiting FER-mediated CRMP2 phosphorylation to enhance paclitaxel on-target activity for cancer therapy
    University of Birmingham Research Portal
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    Oxford University Research Archive

    Alternate Reality Games as Platforms for Practicing 21st-Century Literacies

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    International Journal of Learning and Media
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    Crossref
    Digital Repository at the University of Maryland

    Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

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    'Elsevier BV'
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    Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
    LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas
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    Archivio istituzionale della ricerca - Università di Bari
    Archivio istituzionale della ricerca - Università di Brescia
    Publikationsserver der RWTH Aachen University
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    Brunel University Research Archive
    Archivio istituzionale della ricerca - Università di Padova
    arXiv.org e-Print Archive
    Çukurova University Institutional Repository
    Archivio istituzionale della ricerca - Università di Trieste
    UCrea
    Archivio Istituzionale della Ricerca - Università degli Studi di Pavia
    Ghent University Academic Bibliography
    Archivio istituzionale della Ricerca - Scuola Normale Superiore
    Repository of the Vinča Nuclear Institute (VinaR)
    DIAL UCLouvain
    OpenMETU (Middle East Technical University)
    Explore Bristol Research
    Biblos-e Archivo
    K-State Research Exchange
    Southampton (e-Prints Soton)
    KITopen
    Florence Research
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    DESY
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    Archivio della ricerca - Università degli studi di Napoli Federico II
    Archivio della Ricerca - Università della Basilicata
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    Archivio della Ricerca - Università di Pisa
    OAKTrust Digital Repository (Texas A&M Univ)
    Archivio della ricerca- Università di Roma La Sapienza
    Institutional Research Information System University of Turin
    HAL-Polytechnique

    Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

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    American Meteorological Society
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    The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe
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    Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

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    Riau University
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    This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good
    Neliti

    Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

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    One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI
    Publikationsserver der RWTH Aachen University
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    Archivio della ricerca - Università degli studi di Napoli Federico II
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    Archivio della Ricerca - Università della Basilicata
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    Search for stop and higgsino production using diphoton Higgs boson decays

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    American Physical Society
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    Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass
    LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas
    Archivio istituzionale della ricerca - Università di Brescia
    Publikationsserver der RWTH Aachen University
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    Archivio istituzionale della ricerca - Università di Genova
    Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
    Brunel University Research Archive
    Archivio istituzionale della ricerca - Università di Padova
    Archivio istituzionale della ricerca - Università di Trieste
    Archivio Istituzionale della Ricerca - Università degli Studi di Pavia
    UCrea
    Ghent University Academic Bibliography
    Archivio istituzionale della Ricerca - Scuola Normale Superiore
    Oxford University Research Archive
    Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna
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    Joint Institute for Nuclear Research (JINR)
    Repository of the Vinča Nuclear Institute (VinaR)
    DIAL UCLouvain
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    Explore Bristol Research
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    ePubs: the open archive for STFC research publications
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    Finishing the euchromatic sequence of the human genome

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    LSU Digital Commons
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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
    Louisiana State University
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